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This is a conservative suggestion since older and heavier weight adolescents may be able to consume adult doses of caffeine without suffering adverse effects.

The UK Food Standards Agency has recommended that pregnant women should limit their caffeine intake, out of prudence, to less than 200 mg of caffeine a day – the equivalent of two cups of instant coffee, or one and a half to two cups of fresh coffee.

It can treat and prevent the premature infant breathing disorders bronchopulmonary dysplasia of prematurity and apnea of prematurity.

Caffeine citrate is on the WHO Model List of Essential Medicines.

Some people experience sleep disruption or anxiety if they consume caffeine, but others show little disturbance.

Evidence of a risk during pregnancy is equivocal; some authorities recommend that pregnant women limit consumption to the equivalent of two cups of coffee per day or less.

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Thus it requires roughly 50–100 ordinary cups of coffee to reach a lethal dose.It is the world's most widely consumed psychoactive drug.