Regardless of how oral acepromazine is given, side effects like low and seizures in at-risk individuals are possible.
Sometimes a veterinarian will recommend a medication that is traditionally used for other purposes for its sedative “side effects.” For example, the anti- medications phenobarbital and gabapentin are known to have a profound sedative effect when they are first given to dogs, so they can also be prescribed for use before a potentially stressful event.
A potentially better option is to squirt the injectable, liquid form of acepromazine between the gums and cheek of the dog.
These protocols typically involve teaching dogs to remain calm when they are exposed to mild versions of their triggers, rewarding them, and gradually increasing the intensity of their exposure as long as they remain calm.
Whichever medication is prescribed, make sure to closely follow the dosing instructions that are provided, never give more sedative than is recommended, and talk to your veterinarian about any questions or concerns that you might have.